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Cardiac markers are substances that are released into the bloodstream when the heart is damaged or stressed, making them vital tools in the diagnosis and management of various heart conditions, particularly acute coronary syndrome (ACS), which includes myocardial infarction (MI) or heart attacks. These markers are proteins or enzymes that provide critical information about the health of the heart muscle. The most commonly used cardiac markers include troponin, creatine kinase (CK-MB), and myoglobin. Troponin is often the preferred marker due to its high specificity and sensitivity for cardiac injury; it exists in two forms, troponin I and troponin T, and levels of these proteins can be measured through blood tests. Elevated troponin levels indicate damage to the heart muscle, allowing for the identification of heart attacks even in patients who may exhibit non-specific symptoms. Creatine kinase (specifically CK-MB) is another important marker that helps assess muscle damage, though it can also be released from other muscle tissues; thus, its specificity is lower than that of troponin. The timing of the release of these markers is crucial; troponin can typically be detected in the blood within a few hours of heart damage and may remain elevated for up to two weeks, while CK-MB rises and falls more quickly, becoming detectable within a few hours but returning to normal levels in a few days. Myoglobin is one of the earliest markers to rise after heart injury, but its lack of specificity for cardiac tissue limits its utility in diagnosing heart attacks. In addition to these markers, newer biomarkers such as B-type natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP) are also being studied for their roles in assessing heart failure and cardiovascular risk, respectively. The use of these cardiac markers has revolutionized the approach to diagnosing heart conditions, allowing for quicker decision-making regarding treatment and intervention, especially in emergency settings. Furthermore, their application extends beyond acute events; they can be utilized in the management of chronic heart conditions and in monitoring the effectiveness of treatment strategies. Understanding the levels and dynamics of these markers provides valuable insight into the severity of cardiac injury and guides healthcare professionals in tailoring patient management plans. Overall, the evaluation of cardiac markers represents a critical aspect of modern cardiology, enhancing both diagnostic accuracy and outcome prognostication, while also contributing to the ongoing development of therapeutic interventions aimed at improving cardiovascular health.